Cuddles-Toothy Relationship

As the protagonists and primary characters of the show and class mates, Cuddles and Toothy have arguably the closest relationship in the series. Cuddles and Toothy have been seen together many times throughout the show. It has been shown that they are best friends, and any conflict is extremely rare.

Thickness of Friendship
Both Cuddles and Toothy were one of the first characters to appear on screen and one of the first characters die. They also were the first characters to co-star with someone along with Lumpy and Giggles.

They often participate in activity’s together. In Spin Fun Knowin' Ya and Blast from the Past, they play at the park together with Lumpy and Giggles; in Class Act, they acted in a school play together along with Giggles, Sniffles, and Nutty; in Remains to be Seen, they went trick-or-treating with many other characters; in From A to Zoo, they went on Lumpy’s school field trip along with several other characters; in Take a Hike, they went on a camping trip with the same group of characters with the addition of Nutty; in Snow Place to Go, they went on a sailing trip with several other characters; in Party Animal, they attended Flippy’s birthday party; in Concrete Solution, appear sitting together at the cafe, seemingly having a friendly chat using their eyes given how often they glance at each other; in Autopsy Turvy (Double Whammy Part II), they play dress-up together with Cro-Marmot; in Can't Stop Coffin, they played baseball with Russell and Cro-Marmot; in Wrath of Con, they walk together into the convention center, and later attend Splendid's speech.

Cuddles has shown that he cares about Toothy. In Take a Hike, he watches over Toothy while Lumpy sucks the venom out of Toothy’s arm. Though, while this appears to most likely have been out of concern, there is a distinct possibility that this was at least partially out of curiosity. Similarly, in Snow Place to Go, when Toothy’s nerves freeze on the snow burger, Cuddles is shocked and later saddened by his friend’s injuries. At the beginning of Blast from the Past, he and Giggles both tried to comfort Toothy after he breaks his arm. Cuddles even managed to successfully save Toothy from injury in Autopsy Turvy by catching Toothy when he tripped and was almost impaled in the eye by a coat rack.

Times that they fought
Despite their strong friendship, there have been times where even Toothy is aware of Cuddles's annoyance such as "Camp Pokeyeout".

Cuddles can even be selfish to Toothy such as "From A to Zoo.
 * In From A to Zoo, Cuddles leaves Toothy behind when Lumpy comes over, presumably to have him just be punished
 * In Camp Pokeneyeout, a misunderstanding on Cuddles’ part leads to a full on physical battle with slingshots that many other characters got involved with though Toothy himself with very quick to retaliate and allow the situation to escalate.